Mouse Rho Guanine Nucleotide Exchange Factor 4,ARHGEF4 ELISA KIT

SKU: E1360Mo

Size:96 Tests-1 Kit

Background:Acts as guanine nucleotide exchange factor (GEF) for RHOA, RAC1 and CDC42 GTPases. Binding of APC may activate RAC1 GEF activity. The APC-ARHGEF4 complex seems to be involved in cell migration as well as in E-cadherin-mediated cell-cell adhesion (By similarity). Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Involved in tumor angiogenesis and may play a role in intestinal adenoma formation and tumor progression. {ECO:0000250, ECO:0000269|PubMed:19893577}.

Research_area:

Applications:ELISA

Target_protein:Arhgef4

Reactivity:Mouse

Assay type:Sandwich

Sensitivity:0.09ng/ml

Detection range:0.19-12ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Rho Guanine Nucleotide Exchange Factor 4

Species:Mouse

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q7TNR9

MASS(Da):56679

GeneID:226970

Synonyms:Arhgef4 Kiaa1112

Gene names:Arhgef4

Standard solution:24ng/ml