Mouse Mitotic Checkpoint Serine Threonine-protein Kinase Bub1 Beta, BUB1B ELISA Kit

SKU: E2265Mo

Size:96 Tests-1 Kit

Background:Essential component of the mitotic checkpoint. Required for normal mitosis progression and tumor suppression. The mitotic checkpoint delays anaphase until all chromosomes are properly attached to the mitotic spindle. One of its checkpoint functions is to inhibit the activity of the anaphase-promoting complex/cyclosome (APC/C) by blocking the binding of CDC20 to APC/C, independently of its kinase activity. The other is to monitor kinetochore activities that depend on the kinetochore motor CENPE. Required for kinetochore localization of CENPE. Negatively regulates PLK1 activity in interphase cells and suppresses centrosome amplification. Also implicated in triggering apoptosis in polyploid cells that exit aberrantly from mitotic arrest. Essential for tumor suppression. May play a role in regulating aging and fertility (By similarity).

Research_area:Cell Biology

Applications:ELISA

Target_protein:BUB1B

Reactivity:Mouse

Assay type:Sandwich

Sensitivity:9.08ng/L

Detection range:20-4500ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Mitotic checkpoint serine/threonine-protein kinase BUB1 beta

Species:Mouse

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q9Z1S0

MASS(Da):118,392

GeneID:12236

Synonyms:AU045529;BUB1B;BUBR;BUBR1;MAD3/BUB1-related protein kinase;Mitotic checkpoint kinase MAD3L;Mitotic checkpoint serine/threonine-protein kinase BUB1 beta

Gene names:Bub1b

Standard solution:4800ng/L