Mouse Low Density Lipoprotein Receptor-related Protein 4, LRP4 ELISA Kit

SKU: E2219Mo

Size:96 Tests-1 Kit

Background:Mediates SOST-dependent inhibition of bone formation. Functions as a specific facilitator of SOST-mediated inhibition of Wnt signaling. Plays a key role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between motor neuron and skeletal muscle. Directly binds AGRIN and recruits it to the MUSK signaling complex. Mediates the AGRIN-induced phosphorylation of MUSK, the kinase of the complex. The activation of MUSK in myotubes induces the formation of NMJ by regulating different processes including the transcription of specific genes and the clustering of AChR in the postsynaptic membrane. Alternatively, may be involved in the negative regulation of the canonical Wnt signaling pathway, being able to antagonize the LRP6-mediated activation of this pathway. More generally, has been proposed to function as a cell surface endocytic receptor binding and internalizing extracellular ligands for degradation by lysosomes. Plays an essential role in the process of digit differentiation (PubMed: 16517118).

Research_area:Others

Applications:ELISA

Target_protein:LRP4

Reactivity:Mouse

Assay type:Sandwich

Sensitivity:2.45ng/L

Detection range:5-1000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Low Density Lipoprotein Receptor-Related Protein 4

Species:Mouse

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q8VI56

MASS(Da):211,954

GeneID:228357

Synonyms:LDLR dan;Low-density lipoprotein receptor-related protein 4;LRP 4;LRP4;LRP-4

Gene names:LRP4

Standard solution:1280ng/L