Mouse Interleukin 33, IL-33 ELISA Kit

SKU: E1182Mo

Size:96 Tests-1 Kit

Background:Cytokine that binds to and signals through the IL1RL1/ST2 receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells (PubMed: 29045903). Involved in the maturation of Th2 cells inducing the secretion of T-helper type 2-associated cytokines. Also involved in activation of mast cells, basophils, eosinophils and natural killer cells. Acts as a chemoattractant for Th2 cells, and may function as an 'alarmin', that amplifies immune responses during tissue injury. In quiescent endothelia the uncleaved form is constitutively and abundantly expressed, and acts as a chromatin-associated nuclear factor with transcriptional repressor properties, it may sequester nuclear NF-kappaB/RELA, lowering expression of its targets. This form is rapidely lost upon angiogenic or proinflammatory activation.

Research_area:Cardiovascular; Immunology

Applications:ELISA

Target_protein:IL33

Reactivity:Mouse

Assay type:Sandwich

Sensitivity:9.71ng/L

Detection range:20-4500ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Interleukin 33

Species:Mouse

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q8BVZ5

MASS(Da):29,991

GeneID:77125

Synonyms:IL 33;IL33;IL-33;Interleukin-33

Gene names:IL33

Standard solution:4800ng/L