Mouse Homer Protein Homolog 1, HOMER1 ELISA Kit

SKU: E2137Mo

Size:96 Tests-1 Kit

Background:Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2. Isoform 1 regulates the trafficking and surface expression of GRM5. Differentially regulates the functions of the calcium activated Channel ryanodine receptors RYR1 and RYR2. Isoform 1 decreases the activity of RYR2, and increases the activity of RYR1, whereas isoform 5 counteracts the effects by competing for binding sites. Isoform 3 regulates the trafficking and surface expression of GRM5. Isoform 5 acts as a natural dominant negative, in dynamic competition with constitutively expressed isoform 1, isoform 2 and isoform 3 to regulate synaptic metabotropic glutamate function. Isoform 5, may be involved in the structural changes that occur at synapses during long-lasting neuronal plasticity and development (By similarity). Forms a high-order complex with SHANK1, which in turn is necessary for the structural and functional integrity of dendritic spines (By similarity). Negatively regulates T cell activation by inhibiting the calcineurin-NFAT pathway. Acts by competing with calcineurin/PPP3CA for NFAT protein binding, hence preventing NFAT activation by PPP3CA (By similarity).

Research_area:Others

Applications:ELISA

Target_protein:HOMER1

Reactivity:Mouse

Assay type:Sandwich

Sensitivity:9.79ng/L

Detection range:20-4500ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Homer Protein Homolog 1

Species:Mouse

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q9Z2Y3

MASS(Da):41,413

GeneID:26556

Synonyms:HOMER 1;Homer protein homolog 1;HOMER1;Homer-1;VASP/Ena-related gene up-regulated during seizure and LTP 1;Vesl-1

Gene names:HOMER1

Standard solution:4800ng/L