Mouse Cation-Independent Mannose-6-phosphate Receptor, IGF2R ELISA Kit

SKU: E1913Mo

Size:96 Tests-1 Kit

Background:Mediates the transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelysosomal compartment where the low pH mediates the dissociation of the complex. The receptor is then recycled back to the Golgi for another round of trafficking through its binding to the retromer. This receptor also binds IGF2. Acts as a positive regulator of T-cell coactivation by binding DPP4.

Research_area:Immunology; Stem Cells

Applications:ELISA

Target_protein:IGF2R

Reactivity:Mouse

Assay type:Sandwich

Sensitivity:0.56ng/L

Detection range:1-400ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Cation-independent mannose-6-phosphate receptor

Species:Mouse

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q07113

MASS(Da):273,815

GeneID:16004

Synonyms:300 kDa mannose 6-phosphate receptor;Cation-independent mannose-6-phosphate receptor;CD antigen CD222;CD222;CI-;CI Man-6-P receptor;CI-MPR;IGF2R;IGF-II receptor;Insulin-like growth factor 2 receptor;Insulin-like growth factor II receptor;M6P/IG;M6P/IGF2 receptor;M6P/IGF2R;M6PR;MPR 300;Mpr3;Mpr300

Gene names:Igf2r

Standard solution:480ng/L