Mouse Caspase 6,CASP6 ELISA KIT

SKU: E0787Mo

Size:96 Tests-1 Kit

Background:Cysteine protease that plays essential roles in programmed cell death, axonal degeneration, development and innate immunity (PubMed:18981099, PubMed:23695670, PubMed:32298652). During apoptosis, localizes in the nucleus and cleaves the nuclear structural protein NUMA1 and lamin A/LMNA thereby inducing nuclear shrinkage and fragmentation (By similarity). Furthermore, cleaves many transcription factors such as NF-kappa-B and cAMP response element-binding protein/CREBBP (By similarity). Plays an essential role in axon degeneration during axon pruning which is the remodeling of axons during neurogenesis but not apoptosis (PubMed:23695670). Regulates B-cell programs both during early development and after antigen stimulation (PubMed:18981099, PubMed:29863787). In addition, promotes the ZBP1-mediated activation of programmed cell death pathways including pyroptosis, apoptosis, and necroptosis (PANoptosis) and plays an essential role in defense against viruses (PubMed:32298652). Mechanistically, interacts with RIPK3 and enhances the interaction between RIPK3 and ZBP1, leading to ZBP1-mediated inflammasome activation and cell death (PubMed:32298652). {ECO:0000250|UniProtKB:P55212, ECO:0000269|PubMed:18981099, ECO:0000269|PubMed:23695670, ECO:0000269|PubMed:29863787, ECO:0000269|PubMed:32298652}.

Research_area:

Applications:ELISA

Target_protein:Casp6

Reactivity:Mouse

Assay type:Sandwich

Sensitivity:0.1ng/ml

Detection range:0.19-12ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Caspase 6

Species:Mouse

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:O08738

MASS(Da):31595

GeneID:12368

Synonyms:Casp6

Gene names:Casp6

Standard solution:24ng/ml