Mouse C-C Motif Chemokine 20, CCL20 ELISA Kit

SKU: E2617Mo

Size:96 Tests-1 Kit

Background:Acts as a ligand for C-C chemokine receptor CCR6. Signals through binding and activation of CCR6 and induces a strong chemotactic response and mobilization of intracellular calcium ions (PubMed:9862452, PubMed:20068036). The ligand-receptor pair CCL20-CCR6 is responsible for the chemotaxis of dendritic cells (DC), effector/memory T-cells and B-cells and plays an important role at skin and mucosal surfaces under homeostatic and inflammatory conditions, as well as in pathology, including cancer and autoimmune diseases (PubMed:21376174). CCL20 acts as a chemotactic factor that attracts lymphocytes and, slightly, neutrophils, but not monocytes (By similarity). Involved in the recruitment of both the proinflammatory IL17 producing helper T-cells (Th17) and the regulatory T-cells (Treg) to sites of inflammation (PubMed:19050256). Required for optimal migration of thymic natural regulatory T cells (nTregs) and DN1 early thymocyte progenitor cells (PubMed:24638065). Positively regulates sperm motility and chemotaxis via its binding to CCR6 which triggers Ca2+ mobilization in the sperm which is important for its motility (PubMed:25122636). May be involved in formation and function of the mucosal lymphoid tissues by attracting lymphocytes and dendritic cells towards epithelial cells (PubMed:10064080).

Research_area:Immunology; Signal Transduction

Applications:ELISA

Target_protein:CCL20

Reactivity:Mouse

Assay type:Sandwich

Sensitivity:1.25ng/L

Detection range:2-600ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:C-C motif chemokine 20

Species:Mouse

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:O89093

MASS(Da):10,826

GeneID:20297

Synonyms:Beta-chemokine exodus-1;CC chemokine LARC;CC chemokine ST38;C-C motif chemokine 20;CCL20;CKb4;exodus;exodus-1;LARC;Liver and activation-regulated chemokine;Macrophage inflammatory protein 3 alpha;MI;MIP;MIP-3;MIP-3[a];MIP3A;MIP-3A;MIP-3-alpha;Scya20;Small-inducible cytokine A20;ST3;ST38;

Gene names:Ccl20

Standard solution:640ng/L