Mouse Brain Derived Neurotrophic Facor, BDNF ELISA Kit

SKU: E0013Mo

Size:96 Tests-1 Kit

Background:Important signaling molecule that activates signaling cascades downstream of NTRK2 (PubMed: 27457814). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability (PubMed: 8139657, PubMed: 15486301, PubMed: 17023662, PubMed: 27457814, PubMed: 29909994). [BDNF precursor form]: Important signaling molecule that activates signaling cascades downstream of NTRK2 (PubMed: 27457814). Activates signaling cascades via the heterodimeric receptor formed by NGFR and SORCS2 (PubMed: 24908487, PubMed: 29909994). Signaling via NGFR and SORCS2 plays a role in synaptic plasticity and long-term depression (LTD) (PubMed: 27457814). Binding to NGFR and SORCS2 promotes neuronal apoptosis (PubMed: 24908487). Promotes neuronal growth cone collapse (PubMed: 24908487, PubMed: 27457814).

Research_area:Neuroscience; Cardiovascular; Metabolism

Applications:ELISA

Target_protein:BDNF

Reactivity:Mouse

Assay type:Sandwich

Sensitivity:0.021ng/ml

Detection range:0.05-10ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Brain Derived Neurotrophic Facor

Species:Mouse

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P21237

MASS(Da):28,123

GeneID:12064

Synonyms:BDNF;BDNF precursor form;Brain-derived neurotrophic factor;ProBDNF

Gene names:BDNF

Standard solution:12.8ng/ml