Mouse Autophagy Related Protein 4D, ATG4D ELISA Kit

SKU: E2637Mo

Size:96 Tests-1 Kit

Background:Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Cleaves the C-terminal amino acid of ATG8 family proteins MAP1LC3 and GABARAPL2, to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Has also an activity of delipidating enzyme for the PE-conjugated forms. Plays a role as an autophagy regulator that links mitochondrial dysfunction with apoptosis. The mitochondrial import of ATG4D during cellular stress and differentiation may play important roles in the regulation of mitochondrial physiology, ROS, mitophagy and cell viability (By similarity).

Research_area:Cell Biology

Applications:ELISA

Target_protein:ATG4D

Reactivity:Mouse

Assay type:Sandwich

Sensitivity:10.01ng/L

Detection range:20-3500ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Autophagy related protein 4D

Species:Mouse

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q8BGV9

MASS(Da):52,910

GeneID:235040

Synonyms:9830134P12Rik;Apg;APG4;Apg4d;APG4-D;ATG4D;Aut;Autl4;AUT-like 4 cysteine endopeptidase;Autophagin-4;Autophagy-related cysteine endopeptidase 4;Autophagy-related protein 4 homolog D;Cysteine protease ATG4D;Cysteine protease ATG4D, mitochondrial]

Gene names:Atg4d

Standard solution:4000ng/L