Mouse Arginase-2, ARG2 ELISA Kit

SKU: E1860Mo

Size:96 Tests-1 Kit

Background:May play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis. Extrahepatic arginase functions to regulate L-arginine bioavailability to nitric oxid synthase (NOS). Arginine metabolism is a critical regulator of innate and adaptive immune responses. Seems to be involved in negative regulation of the survival capacity of activated CD4+ and CD8+ T cells (PubMed:27745970, PubMed:25009204). May suppress inflammation-related signaling in asthmatic airway epithelium (PubMed:27214549). May contribute to the immune evasion of H.pylori by restricting M1 macrophage activation and polyamine metabolism (PubMed:27074721). May play a role in promoting prenatal immune suppression (By similarity). Regulates RPS6KB1 signaling, which promotes endothelial cell senescence and inflammation and implicates NOS3/eNOS dysfunction (PubMed:22928666). Can inhibit endothelial autophagy independently of its enzymatic activity implicating mTORC2 signaling (PubMed:25484082). Involved in vascular smooth muscle cell senescence and apoptosis independently of its enzymatic activity (By similarity).

Research_area:Signal Transduction

Applications:ELISA

Target_protein:ARG2

Reactivity:Mouse

Assay type:Sandwich

Sensitivity:0.026ng/mL

Detection range:0.05-20ng/mL

Sample type:Serum, plasma or other biological fluids

Full product name:Arginase-2

Species:Mouse

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:O08691

MASS(Da):38,878

GeneID:11847

Synonyms:AII;ARG2;Arginase II;Arginase-2, mitochondrial;AU022422;Kidney-type arginase;Non-hepatic arginase;Type II arginase

Gene names:Arg2

Standard solution:24ng/mL