MLKL (8H7) Mouse mAb

SKU: EM1328

Size: 100μL

Source:Mouse

Applications:IHC

Reactivity:Human

Dilution:IHC 1:100-200

Immunogen:Synthetic Peptide

Storage_stability:PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.

Clonality:Monoclonal

Isotype:IgG1

Concentration:1mg/mL

Observed_band(KD):54kDa

Human_gene_id:197259

Human_swiss_prot_no:Q8NB16

Subcellular_location:Cell membrane, Cytoplasm, Membrane

Other_name:Mixed lineage kinase domain like protein, FLJ34389

Background:Mixed lineage kinase domain-like protein (MLKL) is a pseudokinase that was identified as downstream target of RIP3 in the necroptosis pathway. During necroptosis RIP3 is phosphorylated at Ser227, which recruits MLKL and leads to its phosphorylation at Thr357 and Ser358.