MKP-3 Polyclonal Antibody

SKU: E-AB-14069

Size: 200μL

Storage: Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping: The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.

Exp date: 12 months

Category ID_II: Primary Antibodies

Category ID_III: Polyclonal Antibodies

Abbreviation: DUSP6

Target Synonym: Dual specificity phosphatase 6;Dual specificity phosphatase 6 isoform a;Dual specificity protein phosphatase 6;Dual specificity protein phosphatase PYST1;DUS6;DUSP 6;DUSP 6a;Dusp6;DUSP6a;HH19;MAP kinase phosphatase 3;Mitogen activated protein kinase phosphatase 3;Mitogen-activated protein kinase phosphatase 3;MKP 3;MKP-3;MKP3;PYST 1;PYST1;Serine/threonine specific protein phosphatase

Research Areas: Cancer;Neuroscience;Signal Transduction

Conjugation: Unconjugated

Host: Rabbit

Species reactivity: Human;Mouse;Rat

Application: IHC

Isotype: IgG

Clonality: Polyclonal

Clone NO.:

UNIProt ID: Q16828

Accession:

Background: The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK2, is expressed in a variety of tissues with the highest levels in heart and pancreas, and unlike most other members of this family, is localized in the cytoplasm. Two transcript variants encoding different isoforms have been found for this gene.

Concentration: 0.5 mg/mL

Immunogen: Recombinant protein of human DUSP6

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Purification method: Affinity purification

Dilution: IHC 1:50-1:200

Calculated MW:

ObservedMW: