Mfn2 rabbit pAb

SKU: ES2784

Size: 100μL

Source:Rabbit

Applications:WB;IHC;IF;ELISA

Reactivity:Human;Mouse;Rat

Dilution:Western Blot: 1/500 - 1/2000. IHC-p: 1:100-300 ELISA: 1/20000. IF 1:100-300 Not yet tested in other applications.

Immunogen:The antiserum was produced against synthesized peptide derived from human Mfn2. AA range:354-403

Storage_stability:-20°C/1 year

Clonality:Polyclonal

Isotype:IgG

Concentration:1 mg/ml

Observed_band(KD):86kD

Human_gene_id:9927

Human_swiss_prot_no:O95140

Subcellular_location:Mitochondrion outer membrane ; Multi-pass membrane protein . Colocalizes with BAX during apoptosis. .

Other_name:MFN2; CPRP1; KIAA0214; Mitofusin-2; Transmembrane GTPase MFN2

Background:This gene encodes a mitochondrial membrane protein that participates in mitochondrial fusion and contributes to the maintenance and operation of the mitochondrial network. This protein is involved in the regulation of vascular smooth muscle cell proliferation, and it may play a role in the pathophysiology of obesity. Mutations in this gene cause Charcot-Marie-Tooth disease type 2A2, and hereditary motor and sensory neuropathy VI, which are both disorders of the peripheral nervous system. Defects in this gene have also been associated with early-onset stroke. Two transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008],