MEIKIN Antibody, Biotin conjugated - Cat. #: CSB-PA20649D0Rb

SKU: CSB-PA20649D0Rb

Size :50ug

Clone Number:

Aliases:MEIKINMeiosis-specific kinetochore protein antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:A0A087WXM9

Immunogen:Recombinant Human Meiosis-specific kinetochore protein (18-91AA)

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA

Background:Key regulator of kinetochore function during meiosis I: required both for mono-orientation of kinetochores on sister chromosomes and protection of centromeric cohesin from separase-mediated cleavage. Acts by facilitating kinetochore mono-orientation during meiosis I, when kinetochores on sister chromosomes face the same direction and are thus captured and pulled by spindle fibers from the same pole. Also required to prevent cleavage of cohesin at centromeres during meiosis I, possibly by acting as a regulator of the shugoshin-dependent protection pathway. Acts in collaboration with PLK1: required for PLK1 enrichment to kinetochores. Not required during meiosis II or mitosis.

Clonality:Polyclonal

Isotype:IgG

Purification Method:>95%, Protein G purified

Conjugate:Biotin

Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:MEIKIN

Research Areas:Others