MED8 Antibody - Cat. #: CSB-PA991036

SKU: CSB-PA991036

Size :100ul

Clone Number:

Aliases:Activator recruited cofactor 32 kDa component antibody; Activator-recruited cofactor 32 kDa component antibody; ARC32 antibody; med8 antibody; MED8_HUMAN antibody; Mediator complex subunit 8 antibody; Mediator of RNA polymerase II transcription subunit 8 antibody; Mediator of RNA polymerase II transcription subunit 8 homolog antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q96G25

Immunogen:Synthesized peptide derived from Internal of Human MED8.

Raised in:Rabbit

Species Reactivity:Human, Mouse, Rat

Tested Applications:ELISA, WB; WB:1:500-1:3000

Background:Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. May play a role as a target recruitment subunit in E3 ubiquitin-protein ligase complexes and thus in ubiquitination and subsequent proteasomal degradation of target proteins.

Brower C.S., Proc. Natl. Acad. Sci. U.S.A. 99:10353-10358(2002).
Gregory S.G., Nature 441:315-321(2006).
Naeaer A.M., Nature 398:828-832(1999).

Clonality:Polyclonal

Isotype:IgG

Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Conjugate:Non-conjugated

Buffer:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Form:liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:MED8

Research Areas:Epigenetics and Nuclear Signaling