MAGEA2 Antibody, HRP conjugated - Cat. #: CSB-PA013327LB01HU

SKU: CSB-PA013327LB01HU

Size :50ug

Clone Number:

Aliases:MAGEA2 antibody; MAGE2 antibody; MAGEA2A; antibody; MAGEA2B antibody; MAGE2 antibody; MAGEA2 antibody; Melanoma-associated antigen 2 antibody; Cancer/testis antigen 1.2 antibody; CT1.2 antibody; MAGE-2 antigen antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:P43356

Immunogen:Recombinant Human Melanoma-associated antigen 2 protein (1-104AA)

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA

Background:Reduces p53/TP53 transactivation function through recruitment of HDAC3 to p53/TP53 transcription sites. Also represses p73/TP73 activity. Proposed to enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. In vitro enhances ubiquitin ligase activity of TRIM28 and stimulates p53/TP53 ubiquitination by TRIM28 potentially in presence of Ubl-conjugating enzyme UBE2H. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. May play a role in embryonal development and tumor transformation or aspects of tumor progression. In vitro promotes cell viability in melanoma cell lines. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes. Negatively regulates acetylation and sumoylation of PML and represses PML-induced p53/TP53 acetylation and activation.

Clonality:Polyclonal

Isotype:IgG

Purification Method:>95%, Protein G purified

Conjugate:HRP

Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:MAGEA2

Research Areas:Cancer; Immunology