MADD Antibody - Cat. #: CSB-PA265032

SKU: CSB-PA265032

Size :100ul

Clone Number:

Aliases:Differentially expressed in normal and neoplastic cells antibody; FLJ35600 antibody; IG20 antibody; Insulinoma glucagonoma clone 20 antibody; KIAA0358 antibody; MADD antibody; MADD_HUMAN antibody; MAP kinase-activating death domain protein antibody; Rab3 GDP/GTP exchange factor antibody; RAB3GEP antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q8WXG6

Immunogen:Synthesized peptide derived from internal of Human MADD.

Raised in:Rabbit

Species Reactivity:Human, Mouse, Rat

Tested Applications:ELISA, WB, IHC, IF; WB:1:500-1:3000, IHC:1:50-1:100, IF:1:100-1:500

Background:Plays a significant role in regulating cell proliferation, survival and death through alternative mRNA splicing. Isoform 5 shows increased cell proliferation and isoform 2 shows decreased. Converts GDP-bound inactive form of RAB3A, RAB3C and RAB3D to the GTP-bound active forms. Component of the TNFRSF1A signaling complex: MADD links TNFRSF1A with MAP kinase activation. Plays an important regulatory role in physiological cell death (TNF-alpha-induced, caspase-mediated apoptosis); isoform 1 is susceptible to inducing apoptosis, isoform 5 is resistant and isoform 3 and isoform 4 have no effect.

Chow V.T.K., DNA Seq. 6:263-273(1996).
Schievella A.R., J. Biol. Chem. 272:12069-12075(1997).
Chow V.T.K., Genome 41:543-552(1998).

Clonality:Polyclonal

Isotype:IgG

Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Conjugate:Non-conjugated

Buffer:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Form:liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:MADD

Research Areas:Cancer;Metabolism