LMP2 Antibody, FITC conjugated - Cat. #: CSB-PA321086HC01EFA

SKU: CSB-PA321086HC01EFA

Size :50ug

Clone Number:

Aliases:LMP2 antibody; Latent membrane protein 2 antibody; Terminal protein antibody

Product Type:Polyclonal Antibody

Immunogen Species:Epstein-Barr virus (strain B95-8) (HHV-4) (Homo sapiens (Human) herpesvirus 4)

UniProt ID:P13285

Immunogen:Recombinant Epstein-Barr virus Latent membrane protein 2 protein (1-147AA)

Raised in:Rabbit

Species Reactivity:Epstein-Barr virus

Tested Applications:

Background:Isoform LMP2A maintains EBV latent infection of B-lymphocyte, by preventing lytic reactivation of the virus in response to surface immunoglobulin (sIg) cross-linking. Acts like a dominant negative inhibitor of the sIg-associated protein tyrosine kinases, LYN and SYK. Also blocks translocation of the B-cell antigen receptor (BCR) into lipid rafts, preventing the subsequent signaling and accelerated internalization of the BCR upon BCR cross-linking. Serves as a molecular scaffold to recruit SYK, LYN and E3 protein-ubiquitin ligases, such as ITCH and NEDD4L, leading to ubiquitination and potential degradation of both tyrosines kinases. Possesses a constitutive signaling activity in non-transformed cells, inducing bypass of normal B lymphocyte developmental checkpoints allowing immunoglobulin-negative cells to colonize peripheral lymphoid organs.

Clonality:Polyclonal

Isotype:IgG

Purification Method:>95%, Protein G purified

Conjugate:FITC

Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:LMP2

Research Areas:Others