LIGO1 Polyclonal Antibody

SKU: BT-AP10904

Size:100μL

Background:Functional component of the Nogo receptor signaling complex (RTN4R/NGFR) in RhoA activation responsible for some inhibition of axonal regeneration by myelin-associated factors. Is also an important negative regulator of oligodentrocyte differentiation and axonal myelination.,PTM:N-glycosylated. Contains predominantly high-mannose glycans.,Contains 1 Ig-like C2-type (immunoglobulin-like) domain.,Contains 13 LRR (leucine-rich) repeats.,subunit:Homotetramer. Forms ternary complex with RTN4R/NGFR and RTN4R/TNFRSF19.,tissue specificity:Expressed exclusively in the central nervous system. Highest level in the in amygdala, hippocampus, thalamus and cerebral cortex. In the rest of the brain a basal expression seems to be always present. Up-regulated in substantia nigra neurons from Parkinson disease patients.,

Research_area:Developmental biology; Neuroscience

Target_protein:LINGO1

applications:WB, ELISA

Reactivity:Human, Mouse

Clonality:Polyclonal

Clone ID:

Host:Rabbit

Isotype:IgG

Gene Symbol/ Name:Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1

Immunogen:The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage:-20°C for 1 year

Purification:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration:1 mg/ml

Molecular weight(Da):

UniProt accession:Human: Q96FE5; Mouse: Q9D1T0

Synonyms:Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 ;Leucine-rich repeat and immunoglobilin domain-containing protein 1;Leucine-rich repeat neuronal pro

GeneID:Human: 84894