lexA Antibody - Cat. #: CSB-PA363985HA01ENV

SKU: CSB-PA363985HA01ENV

Size :50ug

Clone Number:

Aliases:lexA antibody; exrA antibody; spr antibody; tsl antibody; umuA antibody; b4043 antibody; JW4003LexA repressor antibody; EC 3.4.21.88 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Escherichia coli

UniProt ID:P0A7C2

Immunogen:Recombinant Escherichia coli LexA repressor protein (1-202AA)

Raised in:Rabbit

Species Reactivity:Escherichia coli

Tested Applications:ELISA, WB; Recommended dilution: WB:1:500-1:5000

Background:Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. Binds to the 16 bp palindromic sequence 5\\\'-CTGTATATATATACAG-3\\\'. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. Implicated in hydroxy radical-mediated cell death induced by hydroxyurea treatment (PubMed:20005847).The SOS response controls an apoptotic-like death (ALD) induced (in the absence of the mazE-mazF toxin-antitoxin module) in response to DNA damaging agents that is mediated by RecA and LexA (PubMed:22412352).

Clonality:Polyclonal

Isotype:IgG

Purification Method:>95%, Protein G purified

Conjugate:Non-conjugated

Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:lexA

Research Areas:Others