KRT6A Monoclonal Antibody

SKU: BT-MCA3396

Size:100μL

Background:The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. As many as six of this type II cytokeratin (KRT6) have been identified; the multiplicity of the genes is attributed to successive gene duplication events. The genes are expressed with family members KRT16 and/or KRT17 in the filiform papillae of the tongue, the stratified epithelial lining of oral mucosa and esophagus, the outer root sheath of hair follicles, and the glandular epithelia. This KRT6 gene in particular encodes the most abundant isoform. Mutations in these genes have been associated with pachyonychia congenita. In addition, peptides from the C-terminal region of the protein have antimicrobial activity against bacterial pathogens. The type II cytokeratins are clustered in a region of chromosome 12q12-q13.

Research_area:Others

Target_protein:KRT6A

applications:WB, ICC, FCM

Reactivity:

Clonality:Monoclonal

Clone ID:7E3D1

Host:Mouse

Isotype:Mouse IgG2b

Gene Symbol/ Name:KRT6A

Immunogen:Purified recombinant fragment of human KRT6A (AA: 253-352) expressed in E. Coli.

Storage:4°C|-20°C for long term storage

Purification:

Formulation:Purified antibody in PBS with 0.05% sodium azide

Concentration:

Molecular weight(Da):60kDa

UniProt accession:P02538

Synonyms:KRT6A, K6A, K6C, K6D, PC3, CK6C, CK6D, CK-6C, CK-6E, KRT6C, KRT6D

GeneID:3853