KPNA5 Antibody - Cat. #: CSB-PA012487ESR2HU

SKU: CSB-PA012487ESR2HU

Size :50ul

Clone Number:

Aliases:IMA5_HUMAN antibody; Importin alpha 6 antibody; Importin subunit alpha 6 antibody; Importin subunit alpha-6 antibody; IPOA 6 antibody; IPOA6 antibody; Karyopherin alpha 5 antibody; Karyopherin alpha 5 importin alpha 6 antibody; Karyopherin subunit alpha 5 antibody; Karyopherin subunit alpha-5 antibody; KPNA 5 antibody; KPNA5 antibody; SRP 6 antibody; SRP6 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:O15131

Immunogen:Recombinant Human Importin subunit alpha-6 protein (1-240AA)

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA, IHC; Recommended dilution: IHC:1:20-1:200

Background:Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates nuclear import of STAT1 homodimers and STAT1/STAT2 heterodimers by recognizing non-classical NLSs of STAT1 and STAT2 through ARM repeats 8-9. Recognizes influenza A virus nucleoprotein through ARM repeat 7-9 In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS.

Clonality:Polyclonal

Isotype:IgG

Purification Method:Antigen Affinity Purified

Conjugate:Non-conjugated

Buffer:PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:KPNA5

Research Areas:Signal transduction