KIR6.2(Phospho Thr224) Polyclonal Antibody

SKU: BT-AP10704

Size:100μL

Background:Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins and is found associated with the sulfonylurea receptor SUR. Mutations in this gene are a cause of familial persistent hyperinsulinemic hypoglycemia of infancy (PHHI), an autosomal recessive disorder characterized by unregulated insulin secretion. Defects in this gene may also contribute to autosomal dominant non-insulin-dependent diabetes mellitus type II (NIDDM), transient neonatal diabetes mellitus type 3 (TNDM3), and permanent neonatal diabetes mellitus (PNDM). Multiple alternatively spliced trans

Research_area:Cancer; Cardiovascular; Metabolism; Neuroscience; Signal transduction

Target_protein:KCNJ11

applications:WB, IHC-p, IF, ICC, ELISA

Reactivity:Human, Mouse, Rat

Clonality:Polyclonal

Clone ID:

Host:Rabbit

Isotype:IgG

Gene Symbol/ Name:ATP-sensitive inward rectifier potassium channel 11

Immunogen:The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage:-20°C for 1 year

Purification:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration:1 mg/ml

Molecular weight(Da):43562

UniProt accession:Human: Q14654; Mouse: Q61743; Rat: P70673

Synonyms:ATP-sensitive inward rectifier potassium channel 11; KCNJ11; ATP-sensitive inward rectifier potassium channel 11; IKATP; Inward rectifier K;+ channel Kir6.2; Potassium channel; inwardly rectifying subfamily J member 11

GeneID:Human: 3767; Mouse: 16514; Rat: 83535