JUN Polyclonal Antibody

SKU: E-AB-70371

Size::120μL

Storage:Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping:The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Polyclonal Antibodies

Abbreviation:JUN

Target Synonym:Activator protein 1;AP 1;AP1;cJun;Enhancer Binding Protein AP1;Jun Activation Domain Binding Protein;JUN;Jun oncogene;JUN protein;Jun proto oncogene;JUN;JUNC;Oncogene JUN;p39;Proto oncogene c jun;Proto oncogene cJun;Proto-oncogene c-jun;Transcription Factor AP 1;Transcription factor AP-1;Transcription Factor AP1;V jun avian sarcoma virus 17 oncogene homolog;V jun sarcoma virus 17 oncogene homolog (avian);V jun sarcoma virus 17 oncogene homolog;V-jun avian sarcoma virus 17 oncogene homolog;vJun Avian Sarcoma Virus 17 Oncogene Homolog

Research Areas:Cancer;Epigenetics and Nuclear Signaling;Immunology;Signal Transduction

Conjugation:Unconjugated

Host:Rabbit

Species reactivity:Human;Mouse;Rat

Application:IHC

Isotype:IgG

Clonality:Polyclonal

Clone NO.:

UNIProt ID:P05412,P05627,P17325

Accession:

Background:JUN is also named as c-Jun and AP1,belongs to the bZIP family and Jun subfamily. JUN,the most extensively studied protein of the activator protein-1 (AP-1) complex,is involved in numerous cell activities,such as proliferation,apoptosis,survival,tumorigenesis and tissue morphogenesis. JUN is a transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'. It promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. JUN is a basic leucine zipper (bZIP) transcription factor that acts as homo- or heterodimer,binding to DNA and regulating gene transcription. In additon,extracellular signals can induce post-translational modifications of JUN,resulting in altered transcriptional activity and target gene expression. More over,it has uncovered multiple layers of a complex regulatory scheme in which JUN is able to crosstalk,amplify and integrate different signals for tissue development and disease. Jun is predominantly nuclear,ubiquitinated Jun colocalizes with lysosomal proteins.

Concentration:1.1 mg/mL

Immunogen:KLH conjugated Synthetic peptide corresponding to Human c-Jun.

Buffer:PBS with 0.02% sodium azide, 1% protective protein and 50% glycerol, pH7.4

Purification method:Affinity purification

Dilution:IHC 1:500-1:2000

Calculated MW:

ObservedMW: