ITGAE (light chain, Cleaved-Arg177) rabbit pAb

SKU: ES20010

Size: 100μL

Source:Rabbit

Applications:WB;IHC

Reactivity:Human;Rat;Mouse;

Dilution:WB 1:500-2000;IHC-p 1:50-300

Immunogen:Synthesized peptide derived from human ITGAE (light chain, Cleaved-Arg177)

Storage_stability:-20°C/1 year

Clonality:Polyclonal

Isotype:IgG

Concentration:1 mg/ml

Observed_band(KD):17 128kD

Human_gene_id:3682

Human_swiss_prot_no:P38570

Subcellular_location:Membrane; Single-pass type I membrane protein.

Other_name:Integrin alpha-E (HML-1 antigen;Integrin alpha-IEL;Mucosal lymphocyte 1 antigen;CD antigen CD103) [Cleaved into: Integrin alpha-E light chain; Integrin alpha-E heavy chain]

Background:integrin subunit alpha E(ITGAE) Homo sapiens Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes an I-domain-containing alpha integrin that undergoes post-translational cleavage in the extracellular domain, yielding disulfide-linked heavy and light chains. In combination with the beta 7 integrin, this protein forms the E-cadherin binding integrin known as the human mucosal lymphocyte-1 antigen. This protein is preferentially expressed in human intestinal intraepithelial lymphocytes (IEL), and in addition to a role in adhesion, it may serve as an accessory molecule for IEL activation. [provided by RefSeq, Jul 2008],