IRF8 Antibody - Cat. #: CSB-PA011823ESR1HU

SKU: CSB-PA011823ESR1HU

Size :50ul

Clone Number:

Aliases:H ICSBP antibody; H-ICSBP antibody; HGNC:5358 antibody; HICSBP antibody; ICSBP 1 antibody; ICSBP antibody; ICSBP1 antibody; Interferon consensus sequence binding protein 1 antibody; Interferon consensus sequence binding protein antibody; Interferon consensus sequence-binding protein antibody; Interferon regulatory factor 8 antibody; IRF 8 antibody; IRF-8 antibody; Irf8 antibody; IRF8_HUMAN antibody; MYLS antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q02556

Immunogen:Recombinant Human Interferon regulatory factor 8 protein (137-426AA)

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA, IHC; Recommended dilution: IHC:1:20-1:200

Background:Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)). Plays a negative regulatory role in cells of the immune system. Involved in CD8+ dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells, leading to recognition of AICE sequence (5\\\'-TGAnTCA/GAAA-3\\\'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF8 and activation of genes.

Clonality:Polyclonal

Isotype:IgG

Purification Method:Antigen Affinity Purified

Conjugate:Non-conjugated

Buffer:PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:IRF8

Research Areas:Epigenetics and Nuclear Signaling; Immunology