IL1RAP Antibody - Cat. #: CSB-PA878844ESR1HU

SKU: CSB-PA878844ESR1HU

Size :50ul

Clone Number:

Aliases:C3orf13 antibody; FLJ37788 antibody; IL 1 receptor accessory protein antibody; IL 1R 3 antibody; IL 1R3 antibody; IL 1RAcP antibody; IL 1RAP antibody; IL-1 receptor accessory protein antibody; IL-1R-3 antibody; IL-1R3 antibody; IL-1RAcP antibody; IL-1RAP antibody; IL1 receptor accessory protein antibody; IL1AP_HUMAN antibody; IL1R3 antibody; IL1RAcP antibody; Il1rap antibody; Interleukin 1 Accessory Protein antibody; interleukin 1 receptor 3 antibody; Interleukin 1 receptor accessory protein antibody; interleukin 1 receptor accessory protein beta antibody; Interleukin-1 receptor 3 antibody; Interleukin-1 receptor accessory protein antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q9NPH3

Immunogen:Recombinant Human Interleukin-1 receptor accessory protein (21-356AA)

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA, IHC; Recommended dilution: IHC:1:20-1:200

Background:Coreceptor for IL1RL2 in the IL-36 signaling system (By similarity). Coreceptor with IL1R1 in the IL-1 signaling system. Associates with IL1R1 bound to IL1B to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Recruits TOLLIP to the signaling complex. Does not bind to interleukin-1 alone; binding of IL1RN to IL1R1, prevents its association with IL1R1 to form a signaling complex. The cellular response is modulated through a non-signaling association with the membrane IL1R2 decoy receptor. Secreted forms (isoforms 2 and 3) associate with secreted ligand-bound IL1R2 and increase the affinity of secreted IL1R2 for IL1B; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors.

Clonality:Polyclonal

Isotype:IgG

Purification Method:Antigen Affinity Purified

Conjugate:Non-conjugated

Buffer:PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:IL1RAP

Research Areas:Cardiovascular; Immunology