IFIT2 antibody , Cat. # FNab04137

SKU: FNab04137

Size:100ug

Purification:Immunogen affinity purified

Form:liquid

Purity:?95% as determined by SDS-PAGE

Host:Rabbit

Clonality:polyclonal

Clone ID:

Isotype:IgG

Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.)

Background:IFN-induced antiviral protein which inhibits expression of viral messenger RNAs lacking 2'-O-methylation of the 5' cap. The ribose 2'-O-methylation would provide a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Viruses evolved several ways to evade this restriction system such as encoding their own 2'-O-methylase for their mRNAs or by stealing host cap containing the 2'-O-methylation(cap snatching mechanism). Binds AU-rich viral RNAs, with or without 5' triphosphorylation, RNA-binding is required for antiviral activity. Can promote apoptosis.

Immunogen:interferon-induced protein with tetratricopeptide repeats 2

Synonyms:cig42, G10P2, GARG 39, IFI 54, IFI 54K, IFI54, IFIT 2, IFIT2, ISG 54 K, ISG 54K, ISG54

Observed MW:50-55 kDa

Uniprot ID:P09913

Reactivity:Human, Mouse

Tested Application:ELISA, WB, IHC, IF

Recommended dilution:WB: 1:200-1:1000; IHC: 1:50-1:500; IF: 1:10-1:100

Gene ID:3433

Research Area:Immunology