IDH2 Monoclonal Antibody

SKU: BT-MCA3248

Size:100μL

Background:Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the mitochondria. It plays a role in intermediary metabolism and energy production. This protein may tightly associate or interact with the pyruvate dehydrogenase complex. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]

Research_area:Cancer, Metabolism, Signal transduction

Target_protein:IDH2

applications:IHC, FCM

Reactivity:Human

Clonality:Monoclonal

Clone ID:3E8E9

Host:Mouse

Isotype:Mouse IgG1

Gene Symbol/ Name:IDH2

Immunogen:Purified recombinant fragment of human IDH2 (AA: 1-143) expressed in E. Coli.

Storage:4°C|-20°C for long term storage

Purification:

Formulation:Purified antibody in PBS with 0.05% sodium azide

Concentration:

Molecular weight(Da):50.9kDa

UniProt accession:P48735

Synonyms:IDH, IDP, IDHM, IDPM, ICD-M, D2HGA2, mNADP-IDH

GeneID:3418