Human Villin 1, VIL1 ELISA Kit

SKU: E4382hu

Size:96 Tests-1 Kit

Background:Epithelial cell-specific Ca(2+)-regulated actin-modifying protein that modulates the reorganization of microvillar actin filaments. Plays a role in the actin nucleation, actin filament bundle assembly, actin filament capping and severing. Binds phosphatidylinositol 4,5-bisphosphate (PIP2) and lysophosphatidic acid (LPA); binds LPA with higher affinity than PIP2. Binding to LPA increases its phosphorylation by SRC and inhibits all actin-modifying activities. Binding to PIP2 inhibits actin-capping and -severing activities but enhances actin-bundling activity. Regulates the intestinal epithelial cell morphology, cell invasion, cell migration and apoptosis. Protects against apoptosis induced by dextran sodium sulfate (DSS) in the gastrointestinal epithelium. Appears to regulate cell death by maintaining mitochondrial integrity. Enhances hepatocyte growth factor (HGF)-induced epithelial cell motility, chemotaxis and wound repair. Upon S.flexneri cell infection, its actin-severing activity enhances actin-based motility of the bacteria and plays a role during the dissemination.

Research_area:Others

Applications:ELISA

Target_protein:VIL1

Reactivity:Human

Assay type:Sandwich

Sensitivity:5.52ng/L

Detection range:10-2000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Villin 1

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P09327

MASS(Da):92,695

GeneID:7429

Synonyms:VIL 1;VIL1;Villin-1

Gene names:VIL1

Standard solution:2400ng/L