Human Uromodulin, UMOD ELISA Kit

SKU: E4743Hu

Size:96 Tests-1 Kit

Background:[Uromodulin]: Functions in biogenesis and organization of the apical membrane of epithelial cells of the thick ascending limb of Henle's loop (TALH), where it promotes formation of complex filamentous gel-like structure that may play a role in the water barrier permeability (Probable). May serve as a receptor for binding and endocytosis of cytokines (IL-1, IL-2) and TNF (PubMed: 3$498.00|$360.00215). Facilitates neutrophil migration across renal epithelia (PubMed: 20798515). [Uromodulin, secreted form]: In the urine, may contribute to colloid osmotic pressure, retards passage of positively charged electrolytes, prevents urinary tract infection and inhibits formation of liquid containing supersaturated salts and subsequent formation of salt crystals.

Research_area:Others

Applications:ELISA

Target_protein:UMOD

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.51ng/ml

Detection range:1-400ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Uromodulin

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P07911

MASS(Da):69,761

GeneID:7369

Synonyms:Tamm-Horsfall urinary glycoprotein;THP;UMOD;Uromodulin;Uromodulin, secreted form

Gene names:UMOD

Standard solution:480ng/ml