Human Ubiquitin Specific Peptidase 18,USP18 ELISA KIT

SKU: E4837Hu

Size:96 Tests-1 Kit

Background:Involved in the negative regulation of the inflammatory response triggered by type I interferon (PubMed:28165510, PubMed:27325888). Upon recruitment by STAT2 to the type I IFN receptor subunit IFNAR2 interferes with the assembly of the ternary interferon-IFNAR1-IFNAR2 complex and acts as a negative regulator of the type I IFN signaling pathway (PubMed:28165510). Also regulates protein ISGylation. Can efficiently cleave only ISG15 fusions including native ISG15 conjugates linked via isopeptide bonds. Necessary to maintain a critical cellular balance of ISG15-conjugated proteins in both healthy and stressed organisms (PubMed:11788588). {ECO:0000269|PubMed:11788588, ECO:0000269|PubMed:27325888, ECO:0000269|PubMed:28165510}.; [Isoform 2]: Has enzymatic activity similar to isoform 1 and interferes with type I interferon signaling. Major deISGylation enzyme for nuclear proteins (PubMed:22170061). {ECO:0000269|PubMed:22170061}.

Research_area:

Applications:ELISA

Target_protein:USP18

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.12ng/ml

Detection range:0.25-16ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Ubiquitin Specific Peptidase 18

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q9UMW8

MASS(Da):43011

GeneID:11274

Synonyms:USP18 ISG43

Gene names:USP18

Standard solution:32ng/ml