Human Ubiquitin-conjugating Enzyme E2 Variant 1, UBE2V1 ELISA Kit

SKU: E6376Hu

Size:96 Tests-1 Kit

Background:Has no ubiquitin ligase activity on its own. The UBE2V1-UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through Lys-63. This type of poly-ubiquitination activates IKK and does not seem to involve protein degradation by the proteasome. Plays a role in the activation of NF-kappa-B mediated by IL1B, TNF, TRAF6 and TRAF2. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. Promotes TRIM5 capsid-specific restriction activity and the UBE2V1-UBE2N heterodimer acts in concert with TRIM5 to generate 'Lys-63'-linked polyubiquitin chains which activate the MAP3K7/TAK1 complex which in turn results in the induction and expression of NF-kappa-B and MAPK-responsive inflammatory genes. Together with RNF135 and UBE2N, catalyzes the viral RNA-dependent 'Lys-63'-linked polyubiquitination of RIG-I/DDX58 to activate the downstream signaling pathway that leads to interferon beta production (PubMed: 31006531). UBE2V1-UBE2N together with TRAF3IP2 E3 ubiquitin ligase mediate 'Lys-63'-linked polyubiquitination of TRAF6, a component of IL17A-mediated signaling pathway.

Research_area:Others

Applications:ELISA

Target_protein:UBE2V1

Reactivity:Human

Assay type:Sandwich

Sensitivity:34.15ng/L

Detection range:70-15000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Ubiquitin-Conjugating Enzyme E2 Variant 1

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q13404

MASS(Da):16,495

GeneID:3875227335

Synonyms:CROC-1;TRAF6-regulated IKK activator 1 beta Uev1A;UBE 2V1;UBE2V1;Ubiquitin-conjugating enzyme E2 variant 1;UEV-1

Gene names:UBE2V1

Standard solution:16000ng/L