Human Tumor Necrosis Factor Receptor Superfamily Member 14, TNFRSF14 ELISA Kit

SKU: E6641Hu

Size:96 Tests-1 Kit

Background:Receptor for four distinct ligands: The TNF superfamily members TNFSF14/LIGHT and homotrimeric LTA/lymphotoxin-alpha and the immunoglobulin superfamily members BTLA and CD160, altogether defining a complex stimulatory and inhibitory signaling network (PubMed: 9462508, PubMed: 10754304, PubMed: 18193050, PubMed: 23761635). Signals via the TRAF2-TRAF3 E3 ligase pathway to promote immune cell survival and differentiation (PubMed: 19915044, PubMed: 9153189, PubMed: 9162022). Participates in bidirectional cell-cell contact signaling between antigen presenting cells and lymphocytes. In response to ligation of TNFSF14/LIGHT, delivers costimulatory signals to T cells, promoting cell proliferation and effector functions (PubMed: 10754304). Interacts with CD160 on NK cells, enhancing IFNG production and anti-tumor immune response (PubMed: 23761635). In the context of bacterial infection, acts as a signaling receptor on epithelial cells for CD160 from intraepithelial lymphocytes, triggering the production of antimicrobial proteins and proinflammatory cytokines (By similarity). Upon binding to CD160 on activated CD4+ T cells, downregulates CD28 costimulatory signaling, restricting memory and alloantigen-specific immune response (PubMed: 18193050). May interact in cis (on the same cell) or in trans (on other cells) with BTLA (PubMed: 19915044) (By similarity). In cis interactions, appears to play an immune regulatory role inhibiting in trans interactions in naive T cells to maintain a resting state. In trans interactions, can predominate during adaptive immune response to provide survival signals to effector T cells (PubMed: 19915044) (By similarity). (Microbial infection) Acts as a receptor for Herpes simplex virus 1/HHV-1. (Microbial infection) Acts as a receptor for Herpes simplex virus 2/HHV-2.

Research_area:Immunology

Applications:ELISA

Target_protein:TNFRSF14

Reactivity:Human

Assay type:Sandwich

Sensitivity:4.37ng/L

Detection range:10-2000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Tumor Necrosis Factor Receptor Superfamily Member 14

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q92956

MASS(Da):30,392

GeneID:8764

Synonyms:CD antigen CD270;Herpes virus entry mediator A;Herpesvirus entry mediator A;HveA;TNFRSF 14;TNFRSF14;TR2;Tumor necrosis factor receptor superfamily member 14;Tumor necrosis factor receptor-like 2;

Gene names:TNFRSF14

Standard solution:2400ng/L