Human Tryptophan 5-hydroxylase 2, TPH2 ELISA Kit

SKU: E6331Hu

Size:96 Tests-1 Kit

Background:Tryptophan hydroxylase 2 (TPH2) is an isozyme of tryptophan hydroxylase found in vertebrates. In humans, TPH2 is primarily expressed in the serotonergic neurons of the brain, with the highest expression in the raphe nucleus of the midbrain. Until the discovery of TPH2 in 2003, serotonin levels in the central nervous system were believed to be regulated by serotonin synthesis in peripheral tissues, in which tryptophan hydroxylase is the dominant form. Tryptophan hydroxylase (TPH; EC 1.14.16.4) is the rate-limiting enzyme in the synthesis of serotonin (5-hydroxytryptamine, or 5HT). 5HT is causally involved in numerous central nervous activities, and it has several functions in peripheral tissues, including the maintenance of vascular tone and gut motility.

Research_area:Others

Applications:ELISA

Target_protein:TPH2

Reactivity:Human

Assay type:Sandwich

Sensitivity:9.71ng/L

Detection range:20-4500ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Tryptophan 5-hydroxylase 2

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q8IWU9

MASS(Da):56,057

GeneID:121278

Synonyms:ADHD7;Neuronal tryptophan hydroxylase;NTPH;TPH2;Tryptophan 5-hydroxylase 2;Tryptophan 5-monooxygenase 2

Gene names:TPH2

Standard solution:4800ng/L