Human tRNA Methyltransferase 1 61B,TRMT61B ELISA KIT

SKU: E4631Hu

Size:96 Tests-1 Kit

Background:Methyltransferase that catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in various tRNAs in mitochondrion, including tRNA(Leu) (deciphering codons UUA or UUG), tRNA(Lys) and tRNA(Ser) (deciphering codons UCA, UCU, UCG or UCC) (PubMed:23097428). Catalyzes the formation of 1-methyladenosine at position 947 of mitochondrial 16S ribosomal RNA and this modification is most likely important for mitoribosomal structure and function (PubMed:27631568). In addition to tRNA N(1)-methyltransferase activity, also acts as a mRNA N(1)-methyltransferase by mediating methylation of adenosine residues at the N(1) position of MT-ND5 mRNA, leading to interfere with mitochondrial translation (PubMed:29107537). {ECO:0000269|PubMed:23097428, ECO:0000269|PubMed:27631568, ECO:0000269|PubMed:29107537}.

Research_area:

Applications:ELISA

Target_protein:TRMT61B

Reactivity:Human

Assay type:Sandwich

Sensitivity:27.15ng/L

Detection range:50-3200ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:tRNA Methyltransferase 1 61B

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q9BVS5

MASS(Da):52965

GeneID:55006

Synonyms:TRMT61B

Gene names:TRMT61B

Standard solution:6400ng/L