Human TRAILR3/TNFRSF10C ELISA Kit PicoKine®

SKU: EK0533

Size: 96 wells/kit, with removable strips.

Storage: Store at 4℃ for 6 months, at -20℃ for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Form:

Reactivity: Human

Applications: ELISA

Application Details:

Gene Name: TNFRSF10C

Specificity: Natural and recombinant human TRAILR3

Background: TRAILR3/TNFRSF10C is a member of the TNF-receptor superfamily. This receptor contains an extracellular TRAIL-binding domain and a transmembrane domain, but no cytoplasmic death domain. This receptor is not capable of inducing apoptosis, and is thought to function as an antagonistic receptor that protects cells from TRAIL-induced apoptosis. TRAILR3 gene was found to be a p53-regulated DNA damage-inducible gene. The expression of this gene was detected in many normal tissues but not in most cancer cell lines, which may explain the specific sensitivity of cancer cells to the apoptosis-inducing activity of TRAIL.

Immunogen: Expression system for standard: NS0; Immunogen sequence: A26-A236

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Reference:

Uniprot ID: O14798

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Cross Reactivity: There is no detectable cross-reactivity with other relevant proteins.

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Gene ID: 8794

Protein Name: Tumor necrosis factor receptor superfamily member 10C

Gene Full Name: TNF receptor superfamily member 10c

Synonyms: LIT; DCR1; TRID; CD263; TRAILR3; TRAIL-R3; DCR1-TNFR; LIT; UNQ321/PRO366; Tumor necrosis factor receptor superfamily member 10C; Decoy TRAIL receptor without death domain; DcR1