Human TNFRSF12A/TWEAKR ELISA Kit PicoKine®

SKU: EK1753

Size: 96 wells/kit, with removable strips.

Storage: Store at 4℃ for 6 months, at -20℃ for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Form:

Reactivity: Human

Applications: ELISA

Application Details:

Gene Name: TNFRSF12A

Specificity: Natural and recombinant human TNFRSF12A/TWEAKR

Background: The gene for TNFRSF12A was initially recognized as a fibroblast growth factor inducible immediate early response gene Fn14 in mouse NIH 3T3 fibroblasts. This gene is mapped to 16p13.3. Human TNFRSF12A cDNA encodes a 129 amino acid residue type I transmembrane protein with a 27 aa signal peptide, a 53 aa extracellular domain, a 21 aa transmembrane domain and a 28 aa cytoplasmic domain. Human and mouse TNFRSF12A hold 82% aa sequence identity. TNFRSF12 is the tiniest member of the TNF receptor superfamily and has only one cysteine rich region in its extracellular domain. The TNFRSF12A cytoplasmic domain holds one TRAF binding motif which binds TRAFs 1, 2, and 3. TNFRSF12A binds its ligand TWEAK/TNFSF12A with high affinity to initiate a signal transduction cascade which subject to the cell type, causes different cellular responses such as cell death, cell proliferation, and angiogenesis.

Immunogen: Expression system for standard: E.coli; Immunogen sequence: E28-P80

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Reference:

Uniprot ID: Q9NP84

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Cross Reactivity: There is no detectable cross-reactivity with other relevant proteins.

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Gene ID: 51330

Protein Name: Tumor necrosis factor receptor superfamily member 12A

Gene Full Name: TNF receptor superfamily member 12A

Synonyms: TNF receptor superfamily member 12A; CD266; FN14; TWEAKR; TNFRSF12A