Human Tight Junction Protein Zo-1, TJP1 ELISA Kit

SKU: E4353hu

Size:96 Tests-1 Kit

Background:TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed: 7798316, PubMed: 9792688). The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Necessary for lumenogenesis, and particularly efficient epithelial polarization and barrier formation (By similarity). Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells (PubMed: 21240187). Plays an important role in podosome formation and associated function, thus regulating cell adhesion and matrix remodeling (PubMed: 20930113). With TJP2 and TJP3, participates in the junctional retention and stability of the transcription factor DBPA, but is not involved in its shuttling to the nucleus (By similarity).

Research_area:Tags & Cell Markers

Applications:ELISA

Target_protein:TJP1

Reactivity:Human

Assay type:Sandwich

Sensitivity:9.46ng/L

Detection range:20-6000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Tight Junction Protein Zo-1

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q07157

MASS(Da):195,459

GeneID:7082

Synonyms:Tight junction protein 1;Tight junction protein ZO-1;TJP 1;TJP1;Zona occludens protein 1;Zonula occludens protein 1

Gene names:TJP1

Standard solution:6400ng/L