Human Splicing Factor 3B Subunit 1, SF3B1 ELISA Kit

SKU: E6218Hu

Size:96 Tests-1 Kit

Background:Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex (PubMed: 27720643). SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA (PubMed: 12234937). Together with other U2 snRNP complex components may also play a role in the selective processing of microRNAs (miRNAs) from the long primary miRNA transcript, pri-miR-17-92 (By similarity). May also be involved in the assembly of the 'E' complex (PubMed: 10882114). Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron (PubMed: 15146077).

Research_area:Others

Applications:ELISA

Target_protein:SF3B1

Reactivity:Human

Assay type:Sandwich

Sensitivity:9.97ng/L

Detection range:20-6000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Splicing Factor 3B Subunit 1

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:O75533

MASS(Da):145,830

GeneID:23451

Synonyms:Pre-mRNA-splicing factor SF3b 155 kDa subunit;SAP 155;SF3B1;SF3b155;Spliceosome-associated protein 155;Splicing factor 3B subunit 1

Gene names:SF3B1

Standard solution:6400ng/L