Human SPARC ELISA Kit PicoKine®

SKU: EK1210

Size: 96 wells/kit, with removable strips.

Storage: Store at 4℃ for 6 months, at -20℃ for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Form:

Reactivity: Human

Applications: ELISA

Application Details:

Gene Name: SPARC

Specificity: Natural and recombinant human SPARC

Background: SPARC (secreted protein acidic and rich in cysteine), also known as Osteonectin, is a protein that in humans is encoded by the SPARC gene. The human SPARC gene is 26.5 kb long, and contains 10 exons and 9 introns and is located on chromosome 5q31-q33. SPARC is a glycoprotein of 40 kD. SPARC is an acidic, cysteine-rich glycoprotein consisting of a single polypeptide chain that can be broken into 4 domains: 1) an Ca++ binding domains near the glutamic acidic-rich region at the amino terminus (domain I), 2) a cysteine- rich (domain II), 3) a hydrophilic region (domain III) and 4) an EF hand motif at the carboxy terminus region (domain IV). Osteonectin is a glycoprotein in the bone that binds sodium. It is secreted by osteoblasts during bone formation, initiating mineralization and promoting mineral crystal formation. Osteonectin also shows affinity for collagen in addition to bone mineral calcium. A correlation between osteonectin over expression and ampullary cancers and chronic pancreatitis has been found.

Immunogen: Expression system for standard: NS0; Immunogen sequence: A18-I303

Clonality:

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Reference:

Uniprot ID: P09486

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Cross Reactivity: There is no detectable cross-reactivity with other relevant proteins.

Isotype:

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Gene ID: 6678

Protein Name: SPARC

Gene Full Name: secreted protein acidic and cysteine rich

Synonyms: Basement membrane protein 40; BM 40; ON; Osteonectin; SPARC