Human Serine Threonine-protein Phosphatase PP1-beta Catalytic Subunit, PPP1CB ELISA Kit

SKU: E6154Hu

Size:96 Tests-1 Kit

Background:Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase (PP1) is essential for cell division, it participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. May dephosphorylate CSNK1D and CSNK1E. Dephosphorylates the 'Ser-418' residue of FOXP3 in regulatory T-cells (Treg) from patients with rheumatoid arthritis, thereby inactivating FOXP3 and rendering Treg cells functionally defective (PubMed:23396208).

Research_area:Others

Applications:ELISA

Target_protein:PPP1CB

Reactivity:Human

Assay type:Sandwich

Sensitivity:4.92ng/L

Detection range:10-2000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Serine/threonine-protein phosphatase PP1-beta catalytic subunit

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P62140

MASS(Da):37,187

GeneID:5500

Synonyms:HEL-S-80p;MP;NSLH2;PP1B;PP-1B;PP1c;PPP1beta;PPP1CB;PPP1CD;Serine/threonine-protein phosphatase PP1-beta catalytic subunit

Gene names:PPP1CB

Standard solution:2400ng/L