Human Serine Threonine-protein Phosphatase 4 Catalytic Subunit, PPP4C ELISA Kit

SKU: E4812Hu

Size:96 Tests-1 Kit

Background:Protein phosphatase that is involved in many processes such as microtubule organization at centrosomes, maturation of spliceosomal snRNPs, apoptosis, DNA repair, tumor necrosis factor (TNF)-alpha signaling, activation of c-Jun N-terminal kinase MAPK8, regulation of histone acetylation, DNA damage checkpoint signaling, NF-kappa-B activation and cell migration. The PPP4C-PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AX phosphorylated on Ser-140 (gamma-H2AX) generated during DNA replication and required for DNA double strand break repair. Dephosphorylates NDEL1 at CDK1 phosphorylation sites and negatively regulates CDK1 activity in interphase (By similarity). In response to DNA damage, catalyzes RPA2 dephosphorylation, an essential step for DNA repair since it allows the efficient RPA2-mediated recruitment of RAD51 to chromatin.

Research_area:Signal Transduction

Applications:ELISA

Target_protein:PPP4C

Reactivity:Human

Assay type:Sandwich

Sensitivity:11.26ng/L

Detection range:20-3500ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:serine/threonine-protein phosphatase 4 catalytic subunit

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P60510

MASS(Da):35,080

GeneID:5531

Synonyms:PP4;PP4C;PPH3;PPP4;PPP4C;PPX;PP-X;Protein phosphatase X;Serine/threonine-protein phosphatase 4 catalytic subunit;

Gene names:PPP4C

Standard solution:4000ng/L