Human Serine;threonine-protein kinase VRK1,VRK1 ELISA KIT

SKU: E2456Hu

Size:96 Tests-1 Kit

Background:Serine/threonine kinase involved in Golgi disassembly during the cell cycle: following phosphorylation by PLK3 during mitosis, required to induce Golgi fragmentation. Acts by mediating phosphorylation of downstream target protein. Phosphorylates 'Thr-18' of p53/TP53 and may thereby prevent the interaction between p53/TP53 and MDM2. Phosphorylates casein and histone H3. Phosphorylates BANF1: disrupts its ability to bind DNA, reduces its binding to LEM domain-containing proteins and causes its relocalization from the nucleus to the cytoplasm. Phosphorylates ATF2 which activates its transcriptional activity. {ECO:0000269|PubMed:10951572, ECO:0000269|PubMed:14645249, ECO:0000269|PubMed:15105425, ECO:0000269|PubMed:16495336, ECO:0000269|PubMed:18617507, ECO:0000269|PubMed:19103756}.

Research_area:

Applications:ELISA

Target_protein:VRK1

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.1ng/ml

Detection range:0.19-12ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Vaccinia Related Kinase 1

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q99986

MASS(Da):45476

GeneID:7443

Synonyms:VRK1

Gene names:VRK1

Standard solution:24ng/ml