Human Selenoprotein N, SELN ELISA Kit

SKU: E4240hu

Size:96 Tests-1 Kit

Background:[Isoform 2]: Plays an important role in cell protection against oxidative stress and in the regulation of redox-related calcium homeostasis. Regulates the calcium level of the ER by protecting the calcium pump ATP2A2 against the oxidoreductase ERO1A-mediated oxidative damage. Within the ER, ERO1A activity increases the concentration of H(2)O(2), which attacks the luminal thiols in ATP2A2 and thus leads to cysteinyl sulfenic acid formation (-SOH) and SEPN1 reduces the SOH back to free thiol (-SH), thus restoring ATP2A2 activity (PubMed: 25452428). Acts as a modulator of ryanodine receptor (RyR) activity: protects RyR from oxidation due to increased oxidative stress, or directly controls the RyR redox state, regulating the RyR-mediated calcium mobilization required for normal muscle development and differentiation (PubMed: 19557870, PubMed: 18713863). Essential for muscle regeneration and satellite cell maintenance in skeletal muscle (PubMed: 21131290).

Research_area:Others

Applications:ELISA

Target_protein:SELENON

Reactivity:Human

Assay type:Sandwich

Sensitivity:1.53ng/ml

Detection range:3-900ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Selenoprotein N

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q9NZV5

MASS(Da):65,813

GeneID:57190

Synonyms:SELENON;Selenoprotein N;SelN

Gene names:SELENON

Standard solution:960ng/ml