Human Scaffold Attachment Factor B1, SAFB ELISA Kit

SKU: E3949Hu

Size:96 Tests-1 Kit

Background:Binds to scaffold/matrix attachment region (S/MAR) DNA and forms a molecular assembly point to allow the formation of a 'transcriptosomal' complex (consisting of SR proteins and RNA polymerase II) coupling transcription and RNA processing (PubMed: 9671816). Functions as an estrogen receptor corepressor and can also bind to the HSP27 promoter and decrease its transcription (PubMed: 12660241). Thereby acts as a negative regulator of cell proliferation (PubMed: 12660241). When associated with RBMX, binds to and stimulates transcription from the SREBF1 promoter (By similarity).

Research_area:Epigenetics and Nuclear Signaling

Applications:ELISA

Target_protein:SAFB

Reactivity:Human

Assay type:Sandwich

Sensitivity:2.56ng/L

Detection range:5-1000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Scaffold Attachment Factor B1

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q15424

MASS(Da):102,642

GeneID:6294

Synonyms:HSP27 ERE-TATA-binding protein;HSP27 estrogen response element-TATA box-binding protein;SAFB;SAF-B;SAF-B1;Scaffold attachment factor B1

Gene names:SAFB

Standard solution:1280ng/L