Human S100 Calcium Binding Protein A1,S100A1 ELISA KIT

SKU: E4718Hu

Size:96 Tests-1 Kit

Background:Small calcium binding protein that plays important roles in several biological processes such as Ca(2+) homeostasis, chondrocyte biology and cardiomyocyte regulation (PubMed:12804600). In response to an increase in intracellular Ca(2+) levels, binds calcium which triggers conformational changes (PubMed:23351007). These changes allow interactions with specific target proteins and modulate their activity (PubMed:22399290). Regulates a network in cardiomyocytes controlling sarcoplasmic reticulum Ca(2+) cycling and mitochondrial function through interaction with the ryanodine receptors RYR1 and RYR2, sarcoplasmic reticulum Ca(2+)-ATPase/ATP2A2 and mitochondrial F1-ATPase (PubMed:12804600). Facilitates diastolic Ca(2+) dissociation and myofilament mechanics in order to improve relaxation during diastole (PubMed:11717446). {ECO:0000269|PubMed:11717446, ECO:0000269|PubMed:12804600, ECO:0000269|PubMed:22399290, ECO:0000269|PubMed:23351007}.

Research_area:

Applications:ELISA

Target_protein:S100A1

Reactivity:Human

Assay type:Sandwich

Sensitivity:10.91ng/L

Detection range:20-7000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:S100 Calcium Binding Protein A1

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P23297

MASS(Da):10546

GeneID:6271

Synonyms:S100A1 S100A

Gene names:S100A1

Standard solution:8000ng/L