Human Rho GDP-dissociation inhibitor 1,ARHGDIA ELISA KIT

SKU: E7083Hu

Size:96 Tests-1 Kit

Background:Controls Rho proteins homeostasis. Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Retains Rho proteins such as CDC42, RAC1 and RHOA in an inactive cytosolic pool, regulating their stability and protecting them from degradation. Actively involved in the recycling and distribution of activated Rho GTPases in the cell, mediates extraction from membranes of both inactive and activated molecules due its exceptionally high affinity for prenylated forms. Through the modulation of Rho proteins, may play a role in cell motility regulation. In glioma cells, inhibits cell migration and invasion by mediating the signals of SEMA5A and PLXNB3 that lead to inactivation of RAC1. {ECO:0000269|PubMed:20400958, ECO:0000269|PubMed:23434736}.

Research_area:

Applications:ELISA

Target_protein:ARHGDIA

Reactivity:Human

Assay type:Sandwich

Sensitivity:0.07ng/ml

Detection range:0.19-12ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P52565

MASS(Da):23207

GeneID:396

Synonyms:ARHGDIA GDIA1

Gene names:ARHGDIA

Standard solution:24ng/ml