Human Receptor-type Tyrosine-protein Phosphatase Beta, PTPRB ELISA Kit

SKU: E2479Hu

Size:96 Tests-1 Kit

Background:Plays an important role in blood vessel remodeling and angiogenesis. Not necessary for the initial formation of blood vessels, but is essential for their maintenance and remodeling. Can induce dephosphorylation of TEK/TIE2, CDH5/VE-cadherin and KDR/VEGFR-2. Regulates angiopoietin-TIE2 signaling in endothelial cells. Acts as a negative regulator of TIE2, and controls TIE2 driven endothelial cell proliferation, which in turn affects blood vessel remodeling during embryonic development and determines blood vessel size during perinatal growth. Essential for the maintenance of endothelial cell contact integrity and for the adhesive function of VE-cadherin in endothelial cells and this requires the presence of plakoglobin (By similarity).

Research_area:Signal Transduction

Applications:ELISA

Target_protein:PTPRB

Reactivity:Human

Assay type:Sandwich

Sensitivity:9.19ng/L

Detection range:20-7000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Receptor-type tyrosine-protein phosphatase beta

Species:Human

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P23467

MASS(Da):224,301

GeneID:5787

Synonyms:HPTPB;HPTP-BETA;Protein-tyrosine phosphatase beta;PTPB;PTPRB;Receptor-type tyrosine-protein phosphatase beta;R-PTP-BETA;Vascular endothelial protein tyrosine phosphatase;VEPTP;VE-PTP

Gene names:PTPRB

Standard solution:8000ng/L